KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog)

A single nucleotide polymorphism in the bovine kit oncogene (Hardy-Zuckerman 4 feline sarcoma viral (v-kit) oncogene homolog).

BRAF (v-raf murine sarcoma viral oncogene homolog B1)

Multiple oncogenic mutations related to targeted therapy in nasopharyngeal carcinoma.

INTRODUCTION An increasing number of targeted drugs have been tested for the treatment of nasopharyngeal carcinoma (NPC). However, targeted therapy-related oncogenic mutations have not been fully evaluated. This study aimed to detect targeted therapy-related oncogenic mutations in NPC and to determine which targeted therapy might be potentially effective in treating NPC. METHODS By using the ...

Diagnostic, Prognostic, and Predictive Molecular Biomarkers and the Utility of Molecular Imaging in Common Gastrointestinal Tumors

The exponential increase in the use of molecular biomarkers as diagnostic, prognostic, and predictive aids in the management of cancer patients highlights the increasing importance of molecular biology in oncology. The clinical utility of some molecular biomarkers like KRAS (Kirsten rat sarcoma viral oncogene homolog), BRAF (B-Raf protooncogene, serine/threonine kinase), PIK3CA (phosphatidylino...

Mutational Hotspot of TET2, IDH1, IDH2, SRSF2, SF3B1, KRAS, and NRAS from Human Systemic Mastocytosis Are Not Conserved in Canine Mast Cell Tumors.

INTRODUCTION Both canine cutaneous mast cell tumor (MCT) and human systemic mastocytosis (SM) are characterized by abnormal proliferation and accumulation of mast cells in tissues and, frequently, by the presence of activating mutations in the receptor tyrosine kinase V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog (c-KIT), albeit at different incidence (>80% in SM and 10-30% in M...